LTBP4

Across TCGA cell cohorts, LTBP4 mutation is significantly associated with the RNA expression of many other genes, with 564 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LTBP4-associated genes across cancer lineages are OR2AT4, ASB11, and CCDC182. Each is linked with LTBP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LTBP4-to-partner and partner-to-LTBP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2AT4 grouped by LTBP4-low versus LTBP4-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTBP4→partner) and Y-score (partner→LTBP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OR2AT4 →	+0.073	+3.954	<.001	.001	3	2
OVARY	ASB11 →	+0.024	+4.263	.001	.002	3	2
OVARY	CCDC182 →	+0.064	+3.700	<.001	.005	3	2
LARGE_INTESTINE	SEPTIN3 →	+1.262	+3.169	.001	.009	3	2
LARGE_INTESTINE	ZBED4 →	+0.628	+3.364	.001	.002	3	2
LARGE_INTESTINE	ARMC1 →	+0.457	+3.067	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 564 associations by consensus.

OR2AT4 by LTBP4 expression — STOMACH

Explore this box plot interactively →