LTBP3

Across TCGA patient cohorts, LTBP3 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LTBP3-associated genes across cancer lineages are FoxM1, MSH6, and ATM. Each is linked with LTBP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both LTBP3-to-partner and partner-to-LTBP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by LTBP3-low versus LTBP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTBP3→partner) and Y-score (partner→LTBP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.225	+2.000	.027	.010	3	2
UCEC	MSH6 →	-0.322	-2.321	.012	.033	3	2
UCEC	ATM →	-0.744	-3.169	<.001	<.001	3	2
SKCM	Cyclin-B1 →	+0.465	+3.012	.022	.018	2	3
UCEC	JNK2 →	+0.307	+1.710	<.001	.025	3	1
UCEC	MSH2 →	-0.290	-1.990	.001	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

FoxM1 by LTBP3 expression — UCEC

Explore this box plot interactively →