LTBP3

Across TCGA cell cohorts, LTBP3 mutation is significantly associated with the RNA expression of many other genes, with 585 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LTBP3-associated genes across cancer lineages are GIMAP7, PFN3, and SCN2A. Each is linked with LTBP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LTBP3-to-partner and partner-to-LTBP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GIMAP7 grouped by LTBP3-low versus LTBP3-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTBP3→partner) and Y-score (partner→LTBP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GIMAP7 →	+0.051	+4.584	<.001	.001	3	2
CNS	PFN3 →	+0.046	+4.169	<.001	.008	3	2
BLOOD_Leukemia	SCN2A →	+0.559	+3.544	.004	.003	3	2
BLOOD_Leukemia	RAP1GDS1 →	+0.953	+3.115	<.001	.009	3	2
BLOOD_Leukemia	FAXC →	+0.381	+3.328	<.001	.009	3	2
BLOOD_Leukemia	JAKMIP1 →	+2.773	+3.266	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 585 associations by consensus.

GIMAP7 by LTBP3 expression — CNS

Explore this box plot interactively →