LTBP2

Across TCGA pan-cancer cohorts, LTBP2 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of LTBP2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where LTBP2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types LTBP2 is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

COAD, CCRCC, and LSCC are the cancer types where LTBP2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LTBP2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+1.189	<.001	12	view →
CCRCC	All	IV	+1.338	<.001	9	view →
LSCC	Female	All	−1.024	<.001	8	view →
HNSC	Male	IV	+0.670	<.001	8	view →
PDAC	Female	All	+0.970	<.001	6	view →
LUAD	Male	III,IV	−0.552	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

LTBP2–COAD

Open the COAD breakdown →