LTBP2

Across TCGA patient cohorts, LTBP2 mutation is significantly associated with the RNA expression of many other genes, with 7,466 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LTBP2-associated genes across cancer lineages are PBK, MCM5, and PHF5A. Each is linked with LTBP2 in more than 5 cancer types. Because this analysis shows association rather than direction, both LTBP2-to-partner and partner-to-LTBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PBK grouped by LTBP2-low versus LTBP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTBP2→partner) and Y-score (partner→LTBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PBK →	+0.887	+2.258	<.001	<.001	3	6
COAD	MCM5 →	+0.730	+3.807	<.001	<.001	3	5
UCEC	PHF5A →	+0.441	+1.847	<.001	<.001	3	5
UCEC	CDCA5 →	+0.655	+1.513	<.001	<.001	3	5
UCEC	SKA1 →	+0.646	+1.513	<.001	<.001	3	5
UCEC	ORC1 →	+0.740	+2.343	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,466 associations by consensus.

PBK by LTBP2 expression — UCEC

Explore this box plot interactively →