LTBP2

Across TCGA patient cohorts, LTBP2 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LTBP2-associated genes across cancer lineages are Smad4, Cyclin-B1, and FoxM1. Each is linked with LTBP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both LTBP2-to-partner and partner-to-LTBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smad4 grouped by LTBP2-low versus LTBP2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTBP2→partner) and Y-score (partner→LTBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Smad4 →	+0.070	+1.106	.027	.018	3	4
UCEC	Cyclin-B1 →	+0.447	+1.765	.006	.013	3	4
LUAD	FoxM1 →	+0.231	+1.749	.031	.049	3	3
COAD	TSC1 →	-0.396	-2.459	<.001	.018	3	3
UCEC	C-Raf →	+0.160	+1.999	<.001	.008	3	3
LUAD	Lck →	-0.268	-2.321	.003	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

Smad4 by LTBP2 expression — SKCM

Explore this box plot interactively →