LTBP2

Across TCGA cell cohorts, LTBP2 mutation is significantly associated with the RNA expression of many other genes, with 392 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LTBP2-associated genes across cancer lineages are CHCHD4, CNIH1, and ACBD5. Each is linked with LTBP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LTBP2-to-partner and partner-to-LTBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHCHD4 grouped by LTBP2-low versus LTBP2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTBP2→partner) and Y-score (partner→LTBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CHCHD4 →	+0.515	+3.237	.002	.003	3	3
LARGE_INTESTINE	CNIH1 →	+0.478	+2.714	.001	.002	3	2
LARGE_INTESTINE	ACBD5 →	+0.723	+2.628	.003	.002	3	2
LARGE_INTESTINE	FANCE →	+0.445	+3.169	.004	.009	3	2
LARGE_INTESTINE	GOT1 →	+0.597	+3.169	.004	.009	3	2
LARGE_INTESTINE	SLC66A2 →	+0.822	+3.321	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 392 associations by consensus.

CHCHD4 by LTBP2 expression — LARGE_INTESTINE

Explore this box plot interactively →