LTBP1

Across TCGA pan-cancer cohorts, LTBP1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated LTBP1 data layer compared with 27 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher LTBP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated LTBP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

CCRCC, LSCC, and PDAC are the cancer types where LTBP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.139	0.979	.001	71	view →
LSCC	OS	Tertile	II,III,IV	0.490	0.855	.011	16	view →
PDAC	DFS	Median	II,III,IV	0.704	0.858	.001	12	view →
GBM	DFS	Median	All	0.264	0.477	.001	11	view →
COAD	DFS	Quartile	III,IV	0.739	1.000	.046	6	view →
LUAD	DFS	Median	II,III,IV	0.771	0.935	.016	3	view →
HNSC	DFS	Median	II,III,IV	0.864	0.718	.017	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

LTBP1–CCRCC (DFS)

Open the CCRCC breakdown →