Across TCGA pan-cancer cohorts, LTB4R2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of LTB4R2’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LTB4R2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LTB4R2 is over-expressed in tumor, although a few such as THCA and PRAD show the opposite, repressed pattern.
KIRC, KIRP, and BLCA are the cancer types where LTB4R2 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LTB4R2 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.