Across TCGA pan-cancer cohorts, LTB4R mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LTB4R data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher LTB4R mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated LTB4R expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, GBM, and PDAC are the cancer types where LTB4R mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.823	0.552	.026	16	view →
GBM	DFS	Median	All	0.483	0.941	.006	10	view →
PDAC	OS	Median	III,IV	0.333	0.988	.010	6	view →
LUAD	OS	Quartile	II,III,IV	0.495	0.762	.017	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: LTB4R tumor-vs-normal RNA expression · all LTB4R data types