Across TCGA cell cohorts, LTB mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Myeloma shows the largest number of these associations.

The most reproducible LTB-associated genes across cancer lineages are TRIM43B, SMIM43, and C8orf34. Each is linked with LTB in more than 1 cancer types. Because this analysis shows association rather than direction, both LTB-to-partner and partner-to-LTB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTB→partner) and Y-score (partner→LTB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TRIM43B →	+0.014	+2.754	.004	.008	3	1
BLOOD_Myeloma	SMIM43 →	+0.038	+2.736	.001	.005	3	1
BLOOD_Myeloma	C8orf34 →	+0.015	+2.736	.002	.005	3	1
BLOOD_Myeloma	OR2D3 →	+0.043	+3.584	.002	.006	3	1
BLOOD_Myeloma	FAM110D →	+0.189	+2.781	.004	.006	3	1
BLOOD_Myeloma	UTS2 →	+0.766	+3.662	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

LTB survival (RNA) · tumor vs normal (RNA) · all LTB data types