LTA4H

Across TCGA pan-cancer cohorts, LTA4H mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated LTA4H data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LTA4H mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated LTA4H expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where LTA4H mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	III,IV	1.000	0.132	.024	18	view →
PDAC	OS	Median	III,IV	0.591	0.916	.004	7	view →
LUAD	DFS	Tertile	II,III,IV	0.682	0.329	.019	6	view →
CCRCC	DFS	Quartile	III,IV	0.330	0.904	.032	4	view →
LSCC	OS	Median	All	0.878	0.737	.019	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

LTA4H–HNSC (OS)

Open the HNSC breakdown →