LTA

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, LTA mutation is significantly associated with the RNA expression of many other genes, with 1,001 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LTA-associated genes across cancer lineages are STOML2, CDT1, and STIP1. Each is linked with LTA in more than 1 cancer types. Because this analysis shows association rather than direction, both LTA-to-partner and partner-to-LTA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTA→partner) and Y-score (partner→LTA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECSTOML2 →+0.517+3.625.002.00132
UCECCDT1 →+0.923+2.939<.001<.00132
UCECSTIP1 →+0.438+2.906.009.00232
UCECCTU2 →+0.529+2.917<.001.00132
UCECCKS1BP6 →+0.520+2.843<.001<.00132
UCECNCAPH2 →+0.458+2.601.005.00632
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,001 associations by consensus.

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