Across TCGA patient cohorts, LTA mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LTA-associated genes across cancer lineages are ATM, DJ-1, and EGFR_pY1068. Each is linked with LTA in more than 1 cancer types. Because this analysis shows association rather than direction, both LTA-to-partner and partner-to-LTA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTA→partner) and Y-score (partner→LTA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.551	-2.000	.006	.032	3	2
SKCM	DJ-1 →	+0.326	+2.824	.002	.036	3	1
UCEC	EGFR_pY1068 →	-0.283	-2.000	.012	.032	3	1
UCEC	A-Raf_pS299 →	-0.148	-3.000	.005	.036	3	1
UCEC	FoxM1 →	+0.318	+2.700	.006	.006	3	1
UCEC	FOXO3a_pS318_S321 →	-0.114	-2.312	.042	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

LTA survival (RNA) · tumor vs normal (RNA) · all LTA data types