Across TCGA pan-cancer cohorts, LST1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated LST1 data layer compared with 21 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher LST1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated LST1 expression acts as an unfavorable survival marker.

BLCA, COAD, and UCEC are the cancer types where LST1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.132	0.720	<.001	42	view →
COAD	OS	Median	All	0.168	0.806	.002	24	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: LST1 tumor-vs-normal RNA expression · all LST1 data types