Across TCGA patient cohorts, LST1 RNA expression is significantly associated with the protein abundance of many other proteins, with 23,253 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LST1-associated proteins across cancer lineages are ARHGEF6, PTPN6, and RASAL3. Each is linked with LST1 in more than 9 cancer types. Because this analysis shows association rather than direction, both LST1-to-partner and partner-to-LST1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LST1→partner) and Y-score (partner→LST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ARHGEF6 →	+0.561	+0.957	<.001	<.001	3	10
GBM	PTPN6 →	+0.658	+0.870	<.001	<.001	3	10
GBM	RASAL3 →	+0.563	+1.045	<.001	<.001	3	10
LSCC	RASAL3_S72 →	+0.958	+0.929	<.001	<.001	3	10
OV	TNFAIP8L2 →	+0.928	+1.103	<.001	.001	3	10
GBM	ARHGAP45 →	+0.635	+0.798	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 23,253 associations by consensus.

Exploration

LST1 survival (RNA) · tumor vs normal (RNA) · all LST1 data types