Across TCGA patient cohorts, LST1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LST1-associated genes across cancer lineages are RBM17P2, TBL1Y, and MIR5003. Each is linked with LST1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LST1-to-partner and partner-to-LST1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LST1→partner) and Y-score (partner→LST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RBM17P2 →	+0.068	+6.027	<.001	.002	3	1
UCEC	TBL1Y →	+0.159	+5.420	<.001	.005	3	1
UCEC	MIR5003 →	+0.636	+5.133	<.001	.008	3	1
UCEC	RNU6-1318P →	+1.102	+5.358	<.001	.006	3	1
UCEC	RNU6-147P →	+0.619	+5.551	<.001	.004	3	1
UCEC	RN7SKP181 →	+0.239	+5.133	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

LST1 survival (RNA) · tumor vs normal (RNA) · all LST1 data types