LSM7

Across TCGA patient cohorts, LSM7 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible LSM7-associated genes across cancer lineages are RNU6-754P, NCSTNP1, and C4B-AS1. Each is linked with LSM7 in more than 1 cancer types. Because this analysis shows association rather than direction, both LSM7-to-partner and partner-to-LSM7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-754P grouped by LSM7-low versus LSM7-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LSM7→partner) and Y-score (partner→LSM7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-754P →	+0.248	+7.816	<.001	.008	3	1
BLCA	NCSTNP1 →	+0.343	+7.640	<.001	.009	3	1
BLCA	C4B-AS1 →	+0.029	+7.640	<.001	.009	3	1
BLCA	RPL36AP35 →	+0.184	+7.640	<.001	.009	3	1
BLCA	RNA5SP489 →	+0.428	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

RNU6-754P by LSM7 expression — SKCM

Explore this box plot interactively →