LSM5

Across TCGA patient cohorts, LSM5 mutation is significantly associated with the RNA expression of many other genes, with 350 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LSM5-associated genes across cancer lineages are RNA5SP411, RNU7-67P, and RNA5SP410. Each is linked with LSM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both LSM5-to-partner and partner-to-LSM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP411 grouped by LSM5-low versus LSM5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LSM5→partner) and Y-score (partner→LSM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP411 →	+1.589	+2.879	<.001	<.001	3	2
UCEC	RNU7-67P →	+0.297	+3.923	<.001	.009	3	2
UCEC	RNA5SP410 →	+1.018	+2.789	<.001	.001	3	2
UCEC	RNA5SP413 →	+1.430	+2.762	<.001	.001	3	2
UCEC	SERPINA15P →	+0.133	+4.464	<.001	<.001	3	2
UCEC	RN7SL429P →	+0.059	+3.923	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 350 associations by consensus.

RNA5SP411 by LSM5 expression — UCEC

Explore this box plot interactively →