LSM5

Across TCGA patient cohorts, LSM5 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LSM5-associated genes across cancer lineages are CD8+ naive T-cells, CD4+ Tem, and mv Endothelial cells. Each is linked with LSM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both LSM5-to-partner and partner-to-LSM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ naive T-cells grouped by LSM5-low versus LSM5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LSM5→partner) and Y-score (partner→LSM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD8+ naive T-cells →	+0.034	+2.364	.011	.019	3	1
CESC	CD4+ Tem →	+0.002	+7.174	<.001	.013	3	1
UCEC	mv Endothelial cells →	-0.026	-3.000	.027	.036	2	1
UCEC	Plasma cells →	-0.027	-3.416	.013	.005	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CD8+ naive T-cells by LSM5 expression — UCEC

Explore this box plot interactively →