LSM3

Across TCGA patient cohorts, LSM3 mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LSM3-associated genes across cancer lineages are TRAJ28, MIR6769A, and PRAMEF13. Each is linked with LSM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LSM3-to-partner and partner-to-LSM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ28 grouped by LSM3-low versus LSM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LSM3→partner) and Y-score (partner→LSM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAJ28 →	+0.993	+3.132	<.001	.007	3	2
UCEC	MIR6769A →	+0.937	+4.126	.001	.001	3	1
UCEC	PRAMEF13 →	+0.048	+4.132	<.001	.009	3	1
UCEC	MIR3162 →	+0.542	+3.666	<.001	.004	3	1
UCEC	MIR3198-1 →	+0.711	+3.153	.004	.006	3	1
UCEC	SNORD53 →	+0.897	+3.091	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

TRAJ28 by LSM3 expression — UCEC

Explore this box plot interactively →