LSM3

Across TCGA cell cohorts, LSM3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,573 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LSM3-associated GO terms across cancer lineages are Regulation of mitotic sister chromatid separation, Regulation of chromosome separation, and Negative regulation of nuclear division. Each is linked with LSM3 in more than 16 cancer types. Because this analysis shows association rather than direction, both LSM3-to-partner and partner-to-LSM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mitotic sister chromatid separation grouped by LSM3-low versus LSM3-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LSM3→partner) and Y-score (partner→LSM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of mitotic sister chromatid separation →	+0.144	+0.854	.002	.005	3	17
OESOPHAGUS	Regulation of chromosome separation →	+0.140	+0.554	.007	.008	3	17
SKIN	Negative regulation of nuclear division →	+0.145	+0.611	<.001	<.001	3	17
SKIN	Positive regulation of chromosome condensation →	+0.221	+0.682	<.001	<.001	3	16
SKIN	Negative regulation of mitotic sister chromatid separation →	+0.166	+0.588	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Deadenylation-dependent decapping of nuclear-transcribed mRNA →	+0.103	+0.892	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,573 associations by consensus.

Regulation of mitotic sister chromatid separation by LSM3 expression — BREAST

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