LSM14B

Across TCGA pan-cancer cohorts, LSM14B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated LSM14B data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher LSM14B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated LSM14B expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where LSM14B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.738	0.964	.005	35	view →
HNSC	OS	Median	All	0.484	1.000	.038	18	view →
PDAC	OS	Tertile	IV	0.973	0.425	.024	7	view →
GBM	OS	Quartile	All	0.686	0.502	.044	2	view →
LSCC	DFS	Median	All	0.615	0.929	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

LSM14B–CCRCC (OS)

Open the CCRCC breakdown →