LSM14B

Across TCGA patient cohorts, LSM14B mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LSM14B-associated genes across cancer lineages are STAT5a, MEK1, and PRAS40_pT246. Each is linked with LSM14B in more than 1 cancer types. Because this analysis shows association rather than direction, both LSM14B-to-partner and partner-to-LSM14B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT5a grouped by LSM14B-low versus LSM14B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LSM14B→partner) and Y-score (partner→LSM14B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT5a →	+0.441	+2.807	.011	.003	3	2
UCEC	MEK1 →	+0.380	+2.584	.017	.010	3	1
UCEC	PRAS40_pT246 →	+0.168	+1.598	.025	.044	3	1
UCEC	Syk →	+0.337	+1.598	.040	.044	3	1
UCEC	Tuberin_pT1462 →	+0.273	+1.884	.006	.030	3	1
UCEC	Tuberin →	+0.253	+2.115	.031	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

STAT5a by LSM14B expression — UCEC

Explore this box plot interactively →