LSM14A

Across TCGA pan-cancer cohorts, LSM14A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated LSM14A data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher LSM14A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated LSM14A expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

GBM, CCRCC, and LSCC are the cancer types where LSM14A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Quartile	All	0.684	0.261	.003	13	view →
CCRCC	DFS	Tertile	II,III,IV	0.979	0.091	.020	12	view →
LSCC	OS	Median	III,IV	0.441	0.858	.015	7	view →
PDAC	DFS	Quartile	III,IV	1.000	0.442	.040	2	view →
LUAD	DFS	Median	All	0.967	0.834	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

LSM14A–GBM (OS)

Open the GBM breakdown →