LSM14A

Across TCGA patient cohorts, LSM14A mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LSM14A-associated genes across cancer lineages are MEK1, ASNS, and C-Raf. Each is linked with LSM14A in more than 1 cancer types. Because this analysis shows association rather than direction, both LSM14A-to-partner and partner-to-LSM14A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by LSM14A-low versus LSM14A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LSM14A→partner) and Y-score (partner→LSM14A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.430	+2.247	.001	.001	3	2
UCEC	ASNS →	+0.407	+2.700	.002	.006	3	2
UCEC	C-Raf →	+0.164	+2.247	.001	.001	3	2
UCEC	Cyclin-E2 →	+0.164	+2.232	.008	.005	3	2
UCEC	eIF4E →	+0.186	+3.472	.016	.002	3	1
UCEC	eIF4G →	+0.303	+3.321	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

MEK1 by LSM14A expression — UCEC

Explore this box plot interactively →