LSM14A

Across TCGA cell cohorts, LSM14A mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LSM14A-associated genes across cancer lineages are RPL10L, SH3GL2, and LAX1. Each is linked with LSM14A in more than 1 cancer types. Because this analysis shows association rather than direction, both LSM14A-to-partner and partner-to-LSM14A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL10L grouped by LSM14A-low versus LSM14A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LSM14A→partner) and Y-score (partner→LSM14A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RPL10L →	+0.209	+3.839	<.001	.001	3	2
LARGE_INTESTINE	SH3GL2 →	+1.353	+3.252	<.001	.009	3	1
LARGE_INTESTINE	LAX1 →	+0.100	+3.228	<.001	.009	3	1
LARGE_INTESTINE	TEX101 →	+0.233	+3.502	<.001	.004	3	1
LARGE_INTESTINE	MSGN1 →	+0.069	+3.345	<.001	.001	3	1
LARGE_INTESTINE	OR10W1 →	+0.012	+3.240	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

RPL10L by LSM14A expression — LARGE_INTESTINE

Explore this box plot interactively →