LSM12

Across TCGA pan-cancer cohorts, LSM12 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of LSM12’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where LSM12 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LSM12 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

LUAD, HNSC, and BLCA are the cancer types where LSM12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LSM12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	+1.048	<.001	11	view →
HNSC	Male	III,IV	+0.997	<.001	10	view →
BLCA	All	All	+0.687	<.001	10	view →
LUSC	Female	II,III,IV	+1.215	<.001	9	view →
LIHC	Male	All	+0.792	<.001	9	view →
STAD	Male	II,III,IV	+0.772	<.001	9	view →
BRCA	All	III,IV	+0.640	<.001	6	view →
UCEC	All	All	+0.524	.013	6	view →
KIRP	All	II,III,IV	+0.387	.011	6	view →
CHOL	Male	All	+1.448	<.001	5	view →
KICH	Female	All	−0.767	<.001	4	view →
ESCA	All	All	+1.247	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

LSM12–LUAD

Open the LUAD breakdown →