LSM11

Across TCGA patient cohorts, LSM11 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LSM11-associated genes across cancer lineages are EGFR_pY1068, eIF4G, and ERK2. Each is linked with LSM11 in more than 1 cancer types. Because this analysis shows association rather than direction, both LSM11-to-partner and partner-to-LSM11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by LSM11-low versus LSM11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LSM11→partner) and Y-score (partner→LSM11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.310	-3.321	.003	.009	3	1
UCEC	eIF4G →	+0.310	+2.321	.018	.034	3	1
UCEC	ERK2 →	+0.235	+2.222	.004	.011	3	1
UCEC	FASN →	+0.331	+2.321	.048	.034	3	1
UCEC	FoxM1 →	+0.257	+2.222	.019	.011	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.573	+2.009	.007	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

EGFR_pY1068 by LSM11 expression — UCEC

Explore this box plot interactively →