LSM11

Across TCGA cell cohorts, LSM11 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LSM11-associated genes across cancer lineages are ZNF831, VCY1B, and DEFA4. Each is linked with LSM11 in more than 1 cancer types. Because this analysis shows association rather than direction, both LSM11-to-partner and partner-to-LSM11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF831 grouped by LSM11-low versus LSM11-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LSM11→partner) and Y-score (partner→LSM11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF831 →	+0.013	+3.688	<.001	.002	3	1
BREAST	VCY1B →	+1.590	+4.421	<.001	.004	3	1
BREAST	DEFA4 →	+0.035	+4.781	<.001	.003	3	1
BREAST	DEFB125 →	+0.028	+5.312	<.001	<.001	3	1
BLOOD_Leukemia	GUCA1C →	+0.039	+5.969	<.001	.001	3	1
BLOOD_Leukemia	OR4F6 →	+0.028	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ZNF831 by LSM11 expression — LARGE_INTESTINE

Explore this box plot interactively →