LSM1

Across TCGA cell cohorts, LSM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,093 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LSM1-associated GO terms across cancer lineages are Regulation of regulatory ncRNA-mediated heterochromatin formation, Negative regulation of regulatory ncRNA-mediated heterochromatin formation, and Interkinetic nuclear migration. Each is linked with LSM1 in more than 10 cancer types. Because this analysis shows association rather than direction, both LSM1-to-partner and partner-to-LSM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of regulatory ncRNA-mediated heterochromatin formation grouped by LSM1-low versus LSM1-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LSM1→partner) and Y-score (partner→LSM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of regulatory ncRNA-mediated heterochromatin formation →	+0.102	+0.595	.002	.001	2	11
LARGE_INTESTINE	Negative regulation of regulatory ncRNA-mediated heterochromatin formation →	+0.102	+0.595	.002	.001	2	11
BREAST	Interkinetic nuclear migration →	+0.147	+1.241	<.001	<.001	3	9
BREAST	Protein neddylation →	+0.081	+0.987	.006	.002	3	9
SKIN	Protein-DNA complex organization →	+0.046	+0.521	<.001	<.001	3	8
OESOPHAGUS	Protein histidyl modification to diphthamide →	+0.108	+0.648	.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,093 associations by consensus.

Regulation of regulatory ncRNA-mediated heterochromatin formation by LSM1 expression — LARGE_INTESTINE

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