LRWD1

Across TCGA pan-cancer cohorts, LRWD1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated LRWD1 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LRWD1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated LRWD1 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

HNSC, GBM, and LSCC are the cancer types where LRWD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.633	0.872	.006	26	view →
GBM	OS	Quartile	All	0.578	0.309	.004	18	view →
LSCC	DFS	Tertile	II,III,IV	0.895	0.530	.020	11	view →
CCRCC	OS	Median	III,IV	0.133	0.989	.013	10	view →
LUAD	DFS	Quartile	III,IV	0.949	0.424	.013	9	view →
PDAC	OS	Median	IV	0.491	0.836	.024	3	view →
UCEC	OS	Quartile	All	0.887	1.000	.019	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

LRWD1–HNSC (OS)

Open the HNSC breakdown →