LRWD1

Across TCGA patient cohorts, LRWD1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRWD1-associated genes across cancer lineages are p62 Lck ligand, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with LRWD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRWD1-to-partner and partner-to-LRWD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by LRWD1-low versus LRWD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRWD1→partner) and Y-score (partner→LRWD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.335	+3.584	.008	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.546	+2.341	.019	.019	3	2
UCEC	14-3-3_beta →	-0.088	-3.143	.025	.018	3	1
UCEC	A-Raf_pS299 →	-0.116	-2.321	.013	.034	3	1
UCEC	G6PD →	-0.253	-3.156	.046	.018	3	1
UCEC	INPP4B →	-0.274	-1.986	.030	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

p62 Lck ligand by LRWD1 expression — UCEC

Explore this box plot interactively →