LRWD1

Across TCGA cell cohorts, LRWD1 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRWD1-associated genes across cancer lineages are SERPINB3, TBX5, and TEKT3. Each is linked with LRWD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRWD1-to-partner and partner-to-LRWD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SERPINB3 grouped by LRWD1-low versus LRWD1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRWD1→partner) and Y-score (partner→LRWD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SERPINB3 →	+0.439	+4.141	<.001	.001	3	2
OESOPHAGUS	TBX5 →	+0.286	+3.584	<.001	.008	3	1
BLOOD_Leukemia	TEKT3 →	+0.303	+3.553	<.001	.004	3	1
BLOOD_Leukemia	PDE11A →	+0.368	+3.318	<.001	.007	3	1
BLOOD_Leukemia	BTBD16 →	+0.081	+4.181	<.001	<.001	3	1
BLOOD_Leukemia	HABP2 →	+0.245	+3.270	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

SERPINB3 by LRWD1 expression — BLOOD_Leukemia

Explore this box plot interactively →