LRTOMT

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, LRTOMT mutation is significantly associated with the RNA expression of many other genes, with 1,541 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRTOMT-associated genes across cancer lineages are RNA5SP378, RPS15AP9, and RNU6-714P. Each is linked with LRTOMT in more than 2 cancer types. Because this analysis shows association rather than direction, both LRTOMT-to-partner and partner-to-LRTOMT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRTOMT→partner) and Y-score (partner→LRTOMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
SKCMRNA5SP378 →+0.255+3.669<.001.00633
LIHCRPS15AP9 →+0.230+5.547<.001<.00132
LIHCRNU6-714P →+0.398+5.305<.001.00332
LUSCPOTEA →+0.248+3.748.001.00832
UCECATP1B3P1 →+0.209+2.180.004.00932
BRCAOR4A10P →+0.070+6.459<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,541 associations by consensus.

Exploration