Across TCGA patient cohorts, LRTOMT mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRTOMT-associated genes across cancer lineages are ERK2, Di-Ras3, and 14-3-3_beta. Each is linked with LRTOMT in more than 1 cancer types. Because this analysis shows association rather than direction, both LRTOMT-to-partner and partner-to-LRTOMT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRTOMT→partner) and Y-score (partner→LRTOMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.191	+2.087	.009	.005	3	2
UCEC	Di-Ras3 →	-0.126	-3.308	.027	.009	3	2
UCEC	14-3-3_beta →	-0.079	-3.143	.039	.018	3	1
UCEC	eIF4E →	+0.189	+3.183	.019	.009	3	1
UCEC	A-Raf_pS299 →	-0.110	-2.584	.016	.010	3	1
UCEC	Fibronectin →	-0.288	-2.105	.023	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

LRTOMT survival (RNA) · tumor vs normal (RNA) · all LRTOMT data types