LRTM2

Across TCGA patient cohorts, LRTM2 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible LRTM2-associated genes across cancer lineages are pDC, CD4+ Tcm, and CMP. Each is linked with LRTM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRTM2-to-partner and partner-to-LRTM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, pDC grouped by LRTM2-low versus LRTM2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRTM2→partner) and Y-score (partner→LRTM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	pDC →	+0.066	+3.011	.004	.020	3	1
COAD	CD4+ Tcm →	+0.004	+6.156	.010	.018	3	1
LUSC	CMP →	+0.016	+2.730	.042	.027	3	1
BLCA	Keratinocytes →	+0.053	+3.035	.046	.018	1	2
BLCA	Endothelial cells →	-0.052	-2.978	.034	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

pDC by LRTM2 expression — LUAD

Explore this box plot interactively →