LRTM2

Across TCGA cell cohorts, LRTM2 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible LRTM2-associated genes across cancer lineages are OR5M11, MYH2, and OR10Q1. Each is linked with LRTM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRTM2-to-partner and partner-to-LRTM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5M11 grouped by LRTM2-low versus LRTM2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRTM2→partner) and Y-score (partner→LRTM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR5M11 →	+0.048	+4.022	<.001	.006	3	2
SKIN	MYH2 →	+0.138	+3.872	<.001	.002	3	1
STOMACH	OR10Q1 →	+0.097	+5.247	<.001	<.001	3	1
STOMACH	OR6B1 →	+0.015	+4.285	<.001	.007	3	1
STOMACH	RD3L →	+0.045	+4.129	<.001	.007	3	1
LUNG_NSCLC_LUAD	SPINK7 →	+1.608	+3.849	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

OR5M11 by LRTM2 expression — SKIN

Explore this box plot interactively →