LRTM1

Across TCGA patient cohorts, LRTM1 mutation is significantly associated with the RNA expression of many other genes, with 3,100 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRTM1-associated genes across cancer lineages are KRTAP21-1, CCM2L, and SSBP1. Each is linked with LRTM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRTM1-to-partner and partner-to-LRTM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP21-1 grouped by LRTM1-low versus LRTM1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRTM1→partner) and Y-score (partner→LRTM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	KRTAP21-1 →	+0.086	+5.758	<.001	.003	3	3
SKCM	CCM2L →	-0.295	-1.810	.001	.007	3	3
SKCM	SSBP1 →	+0.286	+1.241	<.001	.001	3	3
SKCM	RRP9 →	+0.376	+1.678	<.001	<.001	3	3
UCEC	NDUFAF4 →	+0.648	+2.906	.001	.002	3	3
UCEC	GINS2 →	+0.831	+2.949	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,100 associations by consensus.

KRTAP21-1 by LRTM1 expression — LIHC

Explore this box plot interactively →