LRTM1

Across TCGA patient cohorts, LRTM1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRTM1-associated genes across cancer lineages are FASN, 4E-BP1, and Cyclin-B1. Each is linked with LRTM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRTM1-to-partner and partner-to-LRTM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by LRTM1-low versus LRTM1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRTM1→partner) and Y-score (partner→LRTM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FASN →	+0.484	+2.823	.018	.034	3	2
STAD	4E-BP1 →	+0.373	+3.000	.011	.034	3	2
UCEC	Cyclin-B1 →	+0.941	+2.584	<.001	.011	1	3
SKCM	ACC_pS79 →	+0.184	+1.184	.034	.020	3	1
SKCM	ACC1 →	+0.212	+1.597	.021	.009	3	1
SKCM	HER2_pY1248 →	-0.107	-1.807	.013	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

FASN by LRTM1 expression — STAD

Explore this box plot interactively →