LRSAM1

Across TCGA pan-cancer cohorts, LRSAM1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated LRSAM1 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher LRSAM1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated LRSAM1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, UCEC, and LUAD are the cancer types where LRSAM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.928	0.105	.006	36	view →
UCEC	DFS	Median	All	0.971	0.841	.006	14	view →
LUAD	DFS	Quartile	All	0.942	0.819	.017	4	view →
PDAC	OS	Quartile	III,IV	0.977	0.365	.040	4	view →
HNSC	DFS	Tertile	III,IV	1.000	0.623	.040	3	view →
LSCC	DFS	Quartile	All	0.878	0.964	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

LRSAM1–CCRCC (DFS)

Open the CCRCC breakdown →