LRSAM1

Across TCGA cell cohorts, LRSAM1 mutation is significantly associated with the drug of many other genes, with 40 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRSAM1-associated genes across cancer lineages are PLK_6522, kb NB 142-70, and ETP-45835. Each is linked with LRSAM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRSAM1-to-partner and partner-to-LRSAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLK_6522 grouped by LRSAM1-low versus LRSAM1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRSAM1→partner) and Y-score (partner→LRSAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLK_6522 →	+0.744	+2.649	.023	.046	3	1
LARGE_INTESTINE	kb NB 142-70 →	+0.528	+2.874	.017	.021	3	1
LARGE_INTESTINE	ETP-45835 →	+0.248	+2.874	.030	.021	3	1
LARGE_INTESTINE	FY012 →	+0.475	+2.649	.021	.046	2	1
LARGE_INTESTINE	JAK1_8709 →	+0.390	+2.871	.038	.021	2	1
LARGE_INTESTINE	GSK2110183B →	+0.717	+2.871	.012	.021	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

PLK_6522 by LRSAM1 expression — LARGE_INTESTINE

Explore this box plot interactively →