Across TCGA patient cohorts, LRRTM3 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRTM3-associated genes across cancer lineages are MIG-6, Caspase-7-cleavedD198, and IRS1. Each is linked with LRRTM3 in more than 3 cancer types. Because this analysis shows association rather than direction, both LRRTM3-to-partner and partner-to-LRRTM3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRTM3→partner) and Y-score (partner→LRRTM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIG-6 →	+0.273	+3.000	.013	.036	3	3
UCEC	Caspase-7-cleavedD198 →	+0.649	+1.309	<.001	.013	3	3
SKCM	IRS1 →	+0.217	+2.584	.001	.010	3	3
LUSC	YAP_pS127 →	+0.366	+2.709	.009	.003	3	2
LUAD	PAI-1 →	+1.028	+3.000	.006	.036	1	4
LUAD	4E-BP1 →	+0.418	+3.012	.010	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

Exploration

LRRTM3 survival (RNA) · tumor vs normal (RNA) · all LRRTM3 data types