Across TCGA cell cohorts, LRRTM3 mutation is significantly associated with the RNA expression of many other genes, with 69 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRTM3-associated genes across cancer lineages are SOX17, KLHL40, and ZSWIM2. Each is linked with LRRTM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRTM3-to-partner and partner-to-LRRTM3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRTM3→partner) and Y-score (partner→LRRTM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SOX17 →	+0.361	+2.781	<.001	.008	3	2
BLOOD_Lymphoma	KLHL40 →	+0.013	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	ZSWIM2 →	+0.024	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	CST9 →	+0.119	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	SPAG11A →	+0.111	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	MRGPRG →	+0.056	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

Exploration

LRRTM3 survival (RNA) · tumor vs normal (RNA) · all LRRTM3 data types