LRRN3

Across TCGA patient cohorts, LRRN3 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRN3-associated genes across cancer lineages are GAPDH, MEK1, and 4E-BP1. Each is linked with LRRN3 in more than 3 cancer types. Because this analysis shows association rather than direction, both LRRN3-to-partner and partner-to-LRRN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by LRRN3-low versus LRRN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRN3→partner) and Y-score (partner→LRRN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.380	+2.459	.049	.018	3	4
UCEC	MEK1 →	+0.350	+3.000	.007	<.001	3	3
STAD	4E-BP1 →	+0.361	+3.169	.014	.019	3	3
UCEC	eEF2 →	+0.297	+3.321	.021	.009	3	3
UCEC	PCNA →	+0.175	+3.321	.024	.009	3	3
UCEC	PDCD4 →	-0.435	-1.584	.010	.019	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

GAPDH by LRRN3 expression — UCEC

Explore this box plot interactively →