LRRN2

Across TCGA cell cohorts, LRRN2 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRN2-associated genes across cancer lineages are FOLH1, CST9, and HOXD1. Each is linked with LRRN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRN2-to-partner and partner-to-LRRN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOLH1 grouped by LRRN2-low versus LRRN2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRN2→partner) and Y-score (partner→LRRN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FOLH1 →	+1.261	+3.714	.004	.001	3	2
LUNG_SCLC	CST9 →	+0.012	+3.169	.003	.005	3	2
BLOOD_Lymphoma	HOXD1 →	+0.142	+3.485	.004	.003	3	1
BLOOD_Lymphoma	GKN2 →	+0.116	+3.584	<.001	.004	3	1
BLOOD_Lymphoma	OR2L5 →	+0.042	+3.192	.002	.008	3	1
LARGE_INTESTINE	KRBA1 →	+1.722	+3.125	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

FOLH1 by LRRN2 expression — LARGE_INTESTINE

Explore this box plot interactively →