LRRN1

Across TCGA pan-cancer cohorts, LRRN1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LRRN1 data layer compared with 27 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher LRRN1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRRN1 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

UCEC, GBM, and PDAC are the cancer types where LRRN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.139	1.000	.024	24	view →
GBM	DFS	Median	All	0.496	0.256	<.001	16	view →
PDAC	DFS	Median	All	0.243	0.858	.038	6	view →
LSCC	DFS	Quartile	II,III,IV	0.122	0.868	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

LRRN1–UCEC (DFS)

Open the UCEC breakdown →