LRRN1

Across TCGA patient cohorts, LRRN1 mutation is significantly associated with the RNA expression of many other genes, with 6,418 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRN1-associated genes across cancer lineages are INO80B-WBP1, LMF2, and FAHD2A. Each is linked with LRRN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRN1-to-partner and partner-to-LRRN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INO80B-WBP1 grouped by LRRN1-low versus LRRN1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRN1→partner) and Y-score (partner→LRRN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	INO80B-WBP1 →	+0.112	+3.580	<.001	.003	3	3
UCEC	LMF2 →	+0.418	+3.073	<.001	<.001	3	3
UCEC	FAHD2A →	+0.317	+1.765	<.001	<.001	3	3
SKCM	DYNC2I2 →	+0.354	+1.304	.007	.005	3	3
UCEC	GOT1 →	+0.442	+3.018	<.001	<.001	3	3
UCEC	MRPS2 →	+0.412	+3.917	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,418 associations by consensus.

INO80B-WBP1 by LRRN1 expression — COAD

Explore this box plot interactively →