LRRN1

Across TCGA patient cohorts, LRRN1 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRN1-associated genes across cancer lineages are Ku80, 14-3-3_beta, and eIF4E. Each is linked with LRRN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both LRRN1-to-partner and partner-to-LRRN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by LRRN1-low versus LRRN1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRN1→partner) and Y-score (partner→LRRN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	Ku80 →	+0.371	+3.169	.029	.019	3	3
UCEC	14-3-3_beta →	-0.089	-2.880	.007	.001	3	2
UCEC	eIF4E →	+0.193	+2.201	.006	<.001	3	2
UCEC	p62 Lck ligand →	+0.267	+2.817	.014	.001	3	2
UCEC	PCNA →	+0.217	+1.874	.002	.002	3	2
UCEC	Rad50 →	-0.182	-3.308	.024	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Ku80 by LRRN1 expression — BLCA

Explore this box plot interactively →