LRRN1

Across TCGA cell cohorts, LRRN1 mutation is significantly associated with the RNA expression of many other genes, with 395 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRN1-associated genes across cancer lineages are MAGEB10, CBLL2, and OR4D2. Each is linked with LRRN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRN1-to-partner and partner-to-LRRN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB10 grouped by LRRN1-low versus LRRN1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRN1→partner) and Y-score (partner→LRRN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MAGEB10 →	+0.075	+3.510	<.001	.003	3	2
OVARY	CBLL2 →	+0.036	+5.196	<.001	.005	3	1
OVARY	OR4D2 →	+0.016	+5.196	<.001	.005	3	1
SKIN	HPGDS →	+0.091	+4.145	<.001	.001	3	1
SKIN	CETN1 →	+0.006	+4.022	<.001	.006	3	1
SKIN	SPAG11A →	+0.036	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 395 associations by consensus.

MAGEB10 by LRRN1 expression — SKIN

Explore this box plot interactively →